解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Peimisine, the common ingredient of "zhebeimu" groups and "chuanbeimu" groups, is responsible for the expectorant and cough relieving effects. The aim of this study was to investigate the pharmacokinetics, tissue distribution and excretion of peimisine in male and female SD (Sprague-Dawley) rats by a rapid and sensiti...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-014-0434-1
更新日期:2015-06-01 00:00:00
abstract::We have recently developed betalain-rich beetroot (Beta vulgaris) dye (betalain) to be used in food products. Betalain (30-300 mg/kg) intraperitoneal (i.p.) treatment diminished carrageenan (100 µg/paw)-induced paw edema and neutrophil migration to the paw skin tissue. Betalain (100 mg/kg) treatment by subcutaneous or...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-014-0473-7
更新日期:2015-04-01 00:00:00
abstract::A novel series of fluconazole based mimics incorporating 1,3,4-oxadiazole moiety were designed and synthesized. All the title compounds were characterized by (1)H-NMR, (13)C-NMR, and Q-TOF-MS. Preliminary results revealed that most of analogues exhibited significant antifungal activity against seven pathogenic fungi. ...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-014-0378-5
更新日期:2015-04-01 00:00:00
abstract::The aim of this study was to evaluate a novel 3-fluid concentric nozzle (3-N) spray drying process for the microencapsulation of omeprazole sodium (OME) using Eudragit L100 (EL100). Feed solutions containing OME and/or EL100 in ethanol were assessed visually for OME stability. Addition of OME solution to EL100 solutio...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-013-0261-9
更新日期:2015-04-01 00:00:00
abstract::Human enterovirus 71 (EV71) and Coxsackievirus A16 (CA16) are major causative agents of hand, foot, and mouth disease (HFMD) especially in infants and children under 5 years of age. Despite recent outbreaks of HFMD, there are no approved therapeutics against EV71 and CA16 infection. Moreover, in a small percentage of ...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-014-0390-9
更新日期:2015-02-01 00:00:00
abstract::5-FU is an anticancer drug that is widely used to treat cancers, including colorectal cancer (CRC); however, chemoresistance to 5-FU remains an important problem to be resolved. The role of microRNAs (miRs) in chemosensitivity has recently been studied in the development of therapeutic strategies to overcome drug resi...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-014-0528-9
更新日期:2015-02-01 00:00:00
abstract::In the current study, macrolactin compounds, macrolactin A (MA) and 7-O-succinyl macrolactin A (SMA), were investigated for their anti-angiogenic activities and action mechanism. MA and SMA inhibited in vitro and in vivo angiogenesis induced by three different classes of pro-angiogenic factors, VEGF, IL-8, and TNF-α. ...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-014-0535-x
更新日期:2015-02-01 00:00:00
abstract::Three new sterols, 5α,8α-epidioxy-24-norcholesta-6,9(11),22-trien-3β-ol (1), 5α,8α-epidioxy-cholesta-6,9(11),24-trien-3β-ol (2), and 5α,8α-epidioxy-cholesta-6,23-dien-3β,25-diol (3), with four known sterols (4-7) were isolated from a marine sponge Monanchora sp. Their chemical structures were elucidated by extensive s...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-014-0480-8
更新日期:2015-01-01 00:00:00
abstract::The objective of this study was to investigate the contributions of a sodium-dependent concentrative nucleoside transporter (CNT) 1 and an equilibrative nucleoside transporter (ENT) 1 to ribavirin uptake in human hepatocytes. The initial studies in oocytes expressing CNT1 and ENT1 showed increases in ribavirin uptake,...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-014-0437-y
更新日期:2015-01-01 00:00:00
abstract::It is important to chase the function of islet after transplantation. Thus, we examined the correlation between grafted islets function and molecular imaging intensity using Cy5.5 labeled islet. The ability of Cy5.5-PEG-NHS to chemically bind on the surface of islets was determined by confocal laser scanning microscop...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-014-0412-7
更新日期:2015-01-01 00:00:00
abstract::Berberine, the main active component of the herbal medicine Rhizoma Coptidis, has been reported to have hypoglycemic and insulin-sensitizing effects and, therefore, could be combined with metformin therapy. Thus, we assessed the potential drug-drug interactions between berberine and metformin. We investigated the in v...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-014-0510-6
更新日期:2015-01-01 00:00:00
abstract::Folic acid-decorated self-organized nanoparticles were fabricated to target folate receptor of cancer cells. Doxorubicin (DOX) was conjugated with carboxyl group of dextran backbone using succinic anhydride (DexSU-DOX). DOX-loaded self-organized nanoparticles were prepared by complexation with folic acid-grafted chito...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-014-0489-z
更新日期:2014-12-01 00:00:00
abstract::Chronic inflammation is a major risk factor underlying aging and the associated diseases of aging; of particular interest is insulin resistance during aging. Chronic inflammation impairs normal lipid accumulation, adipose tissue function, mitochondrial function, and causes endoplasmic reticulum (ER) stress, which lead...
journal_title:Archives of pharmacal research
pub_type: 杂志文章,评审
doi:10.1007/s12272-014-0474-6
更新日期:2014-12-01 00:00:00
abstract::A phytochemical study of the grains of S. bicolor, resulting in the isolation of twelve flavonoid glycosides 1-12. Their chemical structures were elucidated on the basis of spectroscopic (1D and 2D NMR) and MS data analyses. All compounds were tested on thrombin time (TT) assay and α-glucosidase assay in order to asse...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-014-0422-5
更新日期:2014-11-01 00:00:00
abstract::A substituted benzamide, amisulpride is an atypical antipsychotic and a specific antagonist for dopamine D2 and D3 receptors. The prandial effect on amisulpride absorption remains unclear, therefore, this study was designed to investigate the effect of food on the systemic exposure to amisulpride in healthy volunteers...
journal_title:Archives of pharmacal research
pub_type: 杂志文章,随机对照试验
doi:10.1007/s12272-014-0331-7
更新日期:2014-10-01 00:00:00
abstract::Our recent data indicate that apotransferrin, an iron-chelating protein, has anti-candidal activity by binding to the Candida albicans surface rather than just simple iron-chelation. Following that study, in this present study, we investigated the nature of the candidal surface substance that is responsible for the an...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-013-0301-5
更新日期:2014-10-01 00:00:00
abstract::The HIV-1 envelope glycoprotein gp120 plays a vital role in the entry of virus into the host cells and is a potential antiviral drug target. Recently, indole derivatives have been reported to inhibit HIV-1 through binding to gp120, and this prevents gp120 and CD4 interaction to inhibit the infectivity of HIV-1. In thi...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-013-0313-1
更新日期:2014-08-01 00:00:00
abstract::Epigallocatechin-3-gallate (EGCG), the major catechin derived from green tea, has been shown to modulate numerous molecular targets in the setting of inflammation. This study aimed to determine whether EGCG protects against regional myocardial ischemia/reperfusion (I/R) injuries and its underlying mechanisms involving...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-013-0309-x
更新日期:2014-08-01 00:00:00
abstract::1-oxoeudesm-11(13)-eno-12,8α-lactone (OEL), a novel eudesmane-type sesquiterpene compound, has been shown to inhibit the growth of some cancer cell lines and induce significant apoptosis. Here, we investigated the anti-cancer activities of OEL in human lung cancer cells. Our studies demonstrated that OEL induced both ...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-013-0270-8
更新日期:2014-08-01 00:00:00
abstract::Topical anesthesia is a safe and cost-effective method considered as the first-choice in many procedures. The objective of the present study was to develop ocular inserts as a new form of lidocaine HCl to give a sufficient level of anesthetic. Ocuserts were prepared using HPMC and PVA in different ratios with lidocain...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-013-0317-x
更新日期:2014-07-01 00:00:00
abstract::The phytochemical investigation of Rudbeckia laciniata L. obtained a new flavonol glycoside (1), together with four flavonol glycosides (2-5) and eight quinic acid derivatives (6-13). The structure was elucidation by means of spectroscopic methods and chemical evidence. The isolated compounds were tested for cytotoxic...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-013-0199-y
更新日期:2014-07-01 00:00:00
abstract::A recent trend in urine drug testing in forensic and clinical toxicology has been the simultaneous determination of different chemical groups of target drugs, which are selected based on their local popularity. Rapid multiple drug analysis, made possible by the use of liquid chromatography-tandem mass spectrometry (LC...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-013-0225-0
更新日期:2014-06-01 00:00:00
abstract::Cytokines that are involved in inflammation are related to blood coagulation, which could indirectly affect warfarin dose requirements. This study aimed to examine the effects of inflammatory cytokine gene polymorphisms on warfarin dose requirements for Korean patients with mechanical heart valves. In total, 191 patie...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-013-0221-4
更新日期:2014-06-01 00:00:00
abstract::Adiponectin is an adipocyte hormone involved in glucose and lipid metabolism. The aim of this study was to develop a human adiponectin expression system in transgenic silkworm using a human adiponectin expression vector. The silk gland of the silkworm is a highly specialized organ that has the wonderful ability to syn...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-013-0298-9
更新日期:2014-05-01 00:00:00
abstract::The aim of this study was to investigate chemical constituents of the leaves of Acanthopanax henryi, and their antioxidant, acetyl cholinesterase inhibitory activities. Caffeoyl quinic acid derivates and flavonoids were obtained from A. henry, through column chromatography technologies, and the content of major consti...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-013-0252-x
更新日期:2014-05-01 00:00:00
abstract::Renal cell carcinoma (RCC) is the most common malignancy of adult human kidney, which accounts for more than 2 % of all cancers. RCC generally does not respond well to conventional chemotherapy and radiotherapy. Cytokine-induced killer (CIK) cells are ex vivo activated lymphocytes with potent activity against various ...
journal_title:Archives of pharmacal research
pub_type: 杂志文章,评审
doi:10.1007/s12272-014-0381-x
更新日期:2014-05-01 00:00:00
abstract::Previous studies have revealed that ingestion of bovine colostrum is effective in preventing pathogens from invading through the gastrointestinal tract (GI) and modulating the mucosal immunity of the GI tract, indicating that its effect is principally local. Thus it is unclear if ingestion of bovine colostrum can affe...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-013-0255-7
更新日期:2014-04-01 00:00:00
abstract::Obesity is a chronic metabolic disease that affects an increasing number of people around the world. There have been limited studies evaluating the weight loss effects of orlistat in the Korean population, whose diet is different from that of the Caucasian population. The primary objective of this study was to evaluat...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-013-0201-8
更新日期:2014-04-01 00:00:00
abstract::Recently a variety of polymeric vehicles, such as micelles, nanoparticles, and polymersomes, have been explored and some of them are clinically used to deliver therapeutic drugs through skin. In topical delivery, the polymeric vehicles as drug carrier should guarantee non-toxicity, long-term stability, and permeation ...
journal_title:Archives of pharmacal research
pub_type: 杂志文章,评审
doi:10.1007/s12272-014-0342-4
更新日期:2014-04-01 00:00:00
abstract::The mucolytic drug ambroxol hydrochloride reduces the production of pro-inflammatory cytokines and the frequency of exacerbation in patients with chronic obstructive pulmonary disease (COPD). However, the inhibitory effects of ambroxol on rhinovirus infection, the major cause of COPD exacerbations, have not been studi...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-013-0210-7
更新日期:2014-04-01 00:00:00
abstract::Baicalin (baicalein-7-glucuronide) is a flavonoid purified from Scutellaria baicalensis Georgi that has traditionally been used for treatment of hypertension, cardiovascular diseases, and viral hepatitis. In this study, the effects of intestinal microbiota on the pharmacokinetics of baicalin were investigated in norma...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-013-0179-2
更新日期:2014-03-01 00:00:00
abstract::Radix Astragali (Astragalus membranaceus) is an important traditional Chinese medicine that is widely used as a tonic to enhance the body's natural defense mechanisms. In this phytochemical study, 12 flavonoids, isoliquiritigenin (1), liquiritigenin (2), calycosin (3), calycosin 7-O-β-D-glucoside (4), formononetin (5)...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-013-0174-7
更新日期:2014-02-01 00:00:00
abstract::It has been reported that transferrin has antibacterial and antifungal activities via iron chelation in the environment surrounding the microbes. In the present study, we investigated whether the binding of transferrin to Candida albicans mediates growth inhibition. By using cultures that contained iron-free (apo)tran...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-013-0263-7
更新日期:2014-02-01 00:00:00
abstract::Cirsium japonicum (CJ) has been shown to possess antidepressant-like properties. In the present study, we sought to identify which constituent of CJ might be responsible for its antidepressant effects and determine probable mechanism of action. The ethanol extract of CJ was administered to mice then behavioral changes...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-013-0229-9
更新日期:2014-02-01 00:00:00
abstract::Fermentation of natural products is emerging as an important processing method and is attracting a lot of attention because it may have the advantage of having a new biological function. In this study, fruits of Opuntia ficus-indica were enzymatically hydrolyzed and then fermented with two species of yeast. We identif...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-013-0320-2
更新日期:2014-01-01 00:00:00
abstract::Magnetic nanoparticles have been subjected to extensive studies in the past few decades owing to their promising potentials in biomedical applications. The versatile intrinsic properties of magnetic nanoparticles enable their use in many biomedical applications. Recently, magnetic nanoparticles were utilized to contro...
journal_title:Archives of pharmacal research
pub_type: 杂志文章,评审
doi:10.1007/s12272-013-0303-3
更新日期:2014-01-01 00:00:00
abstract::The present work describes the synthesis and evaluation of some new acetohydrazones, 1,3,4-oxadiazoles and 1,2,4-triazoles of 1,2,4-triazolo[1,5-a]benzimidazole as anti-inflamm atory-analgesic agents. Structure elucidation of these compounds was confirmed by IR, (1)H NMR, and mass spectrometry along with elemental mic...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-013-0153-z
更新日期:2013-12-01 00:00:00
abstract::Recent advances in the search for novel anticancer agents have indicated that the positively charged antimicrobial peptides have emerged as promising agents offering several advantages over the conventional anticancer drugs. As a naturally occurring, cationic, α-helical antimicrobial peptide, temproin-1CEa has been pr...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-013-0112-8
更新日期:2013-11-01 00:00:00
abstract::The cancers are a series of serious diseases in the world, and the mechanism involved in many cancers has not yet been fully elucidated. Therefore, it is a very major and significant to explore the molecular mechanisms of cancer occurence and development. MicroRNAs (miRNAs), a class of molecules that regulates gene at...
journal_title:Archives of pharmacal research
pub_type: 杂志文章,评审
doi:10.1007/s12272-013-0213-4
更新日期:2013-10-01 00:00:00
abstract::As part of our ongoing search for natural sources of therapeutic and preventive agents for diabetic complications, we evaluated the inhibitory effects of components of the fruit of Xanthium strumarium (X. strumarium) on aldose reductase (AR) and galactitol formation in rat lenses with high levels of glucose. To identi...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-013-0123-5
更新日期:2013-09-01 00:00:00